Chemistry and Biology: Pharmaceutical Research and Development, Production and Pharmacological Analysis

Course 6: Chemistry and Biology: Pharmaceutical Research and Development, Production and Pharmacological Analysis

II. Course Description

Biomedical science is the intersection of biology, medicine, and related science in living systems (including humans). It covers a wide range of topics, including physiology, pathology, pharmacology, molecular biology, genomics, medical imaging, and much more. The goal of biomedicine is to understand the normal functioning and abnormal state of living systems, and to develop ways to prevent, diagnose, and treat diseases. A lot of our most important drugs are antibiotics. Antibiotics are defined as small molecules produced by one microorganism that kill or impair the growth of another microorganism. These molecules are likely to be used for chemical defense in nature, but they have long been used in biological research, biotechnology, and medicine. One of the most famous antibiotics in medicine is the antimicrobial drug called penicillin.

This course aims to highlight the link between chemistry and biology. This course will cover a wide range of topics in chemistry and biology. This course is open to students from biological and / or chemical science backgrounds. Students with chemical background will learn the basic concepts of biology; students with solid biological knowledge will learn the basic concepts of chemistry. The course assumes that students are familiar with the basic concepts of organic chemistry, biochemistry, and genetics.

II. Professor Introduction

Jason Sello – Tenured professor, at the University of California, San Francisco

Jason Sello Is a tenured professor in the Department of Medicinal chemistry at the University of California, San Francisco (UCSF) and a member of the executive committee of the department. Jason Sello Also served as a professor of Chemistry at Brown University. His research interests include the development of new synthesis methods and their application in the total synthesis of natural products. Dr. Sello received his PhD in chemistry from Harvard University and completed his post-doctoral studies at MIT. Dr. Sellos research focuses on bacterial proteins, especially those related to drug resistance in bacteria such as Streptomyces and Mycobacterium tuberculosis.

His research work has won many awards, including the National Science Foundation (NSF) CAREER Award and the Eli Lilly Funder Award. His work were published in various scientific journals on topics including the development of small molecules to restore drug activity against drug-resistant Candida isolates and thermal copolymer nanocarriers for the treatment of leishmaniasis infections. Professor Sello was also awarded the Department of Energy Early Career Research Award in 2012 for his research work. In addition, in 2020, he was selected as “1,000 American inspirational Black Scientists” by Cell Press.

III. Syllabus

1. Basic concepts of antibiotics and microorganisms
2. Streptomycin; tuberculosis and Mycobacterium tuberculosis; Staphylococcus cinerea
3. Structure and definition of aminoglycoside; mechanism of action of streptomycin
4. Erythromycin; erythrocyte yeast; macrolide and aglycone
5. Mechanism of action of erythromycin; resistance mechanism of erythromycin
6. Tyrosinycin; Bacillus; tyrosinase; antibiotic peptides
7. particularity of tyrosine; synthesis of tyrosine side and ramie
8. Non-ribosomal peptide synthesis; biosynthesis of casamidine; functional domains
9. Biochemistry and genetics: antibiotic production routes
10. 10 Genetic engineering to produce known antibiotics and their derivatives