Immunology: Research on Vaccines, Immune System and Antitumor Drugs

Course 1: Immunology: Research on Vaccines, Immune System and Antitumor Drugs

I. Course Description

In the medical field, immunology, as a key field, is dedicated to studying the function of the human immune system, the regulatory mechanisms, and the impact of the immune response on disease. With the development of science and technology, immunology has gradually integrated into many medical fields, especially the remarkable progress in vaccine development, immunotherapy and antitumor drugs.

This course addresses fundamental aspects of the mammalian immune system, including its composition and function. Topics covered include basic immune system characteristics of the innate and acquired immune systems, diversity of the immune system, antigen presentation, T cells, B cells, as well as immune effector functions, and an overview of immune function and deregulation in health and disease at the end of the course. Students should actively participate in the classroom and propose clinical case studies based on immunology, followed by a discussion of the case and the general concepts involved in it.

II. Professor Introduction

Alexander Ploss – Tenured Professor, Department of Molecular Biology, Princeton University

Professor Alexander Ploss is a tenured professor in the Department of Molecular Biology at Princeton University and has the personal naming laboratory Ploss Lab. His research focuses on the immune response and pathogenesis of human infectious diseases, including hepatitis viruses, associated flaviviruses, and malaria. His team combines tissue engineering, molecular virology pathogenesis and animal structure to create and combine humanized mouse models for research and intervention in human liver disease infections.

Professor Ploss has won the Kimberly-Lawrence Cancer Research Discovery Fund Award (Kimberly Lawrence Cancer Research Discovery Fund Award), the Astra Young Researcher Award (Astellas Young Investigator Award) from the Infectious Diseases Society of America, and the Liver Scholar Award (Liver Scholar Award) from the American Liver Foundation. In addition, Professor Ploss is a member of the Genomic Instability and Tumor Progress Project at the Cancer Institute of New Jersey. He is frequently invited to address international conferences and seminars and is on the editorial board of several prominent scientific journals in the fields of virology and immunology.

III. Syllabus

1. Introduction to immunology; innate immunity: the first line of defense
2. Innate immunity: the complement system; the induction of innate immunity
3. Antigen recognition of B cell and T cell receptors; antigen receptors
4. Lymphocyte antigen receptor; antigen presentation by T lymphocytes
5. MHC and its function; signaling through the receptors of the immune system
6. 6, for the development of B & T cells
7. Thymic selection; lymphocyte homing and priming
8. 8.T-cell effector function; B-cell activation
9. Distribution and function of Ig categories; Fc receptor; immunological memory
10. Dynamics of adaptive immunity; cancer immunity